Bioinformatician (m/f) 80-100% - in translational research teams in pediatric cancer at Universitäts Kinderspital Zürich (Zürich, ZH, Switzerland) | Careerkit Jobs
The exact salary will depend on your qualifications and professional experience.
Beschreibung
Your responsibilities
As a key computational partner within a collaborative research environment, you will provide bioinformatics expertise across research groups, developing reproducible analysis workflows, integrating diverse omics datasets, and translating complex data into meaningful biological insights.
In this role, analyzing high-throughput sequencing data (WGS, WES, RNA-seq, single-cell RNA-seq, and ATAC-seq), as well as metabolomic and proteomic datasets, will be a central responsibility.
Your expertise will be essential for developing, optimizing, and maintaining robust and reproducible computational pipelines for variant calling, differential expression analysis, and related bioinformatics workflows.
A key aspect of your work will be the integration of public cancer genomics datasets with internal and external experimental data to support innovative research projects.
Working closely with researchers across disciplines, you will provide statistical support, create insightful data visualizations, and contribute to the biological interpretation of complex datasets.
Supporting the laboratory's computational infrastructure, you will maintain code repositories, improve workflow documentation, and ensure effective data storage management.
Your contributions will extend to the preparation of scientific manuscripts, grant applications, and research progress reports.
Aufgaben
As a key computational partner within a collaborative research environment, you will provide bioinformatics expertise across research groups, developing reproducible analysis workflows, integrating diverse omics datasets, and translating complex data into meaningful biological insights.
Analyzing high-throughput sequencing data (WGS, WES, RNA-seq, single-cell RNA-seq, and ATAC-seq), as well as metabolomic and proteomic datasets.
Developing, optimizing, and maintaining robust and reproducible computational pipelines for variant calling, differential expression analysis, and related bioinformatics workflows.
Integrating public cancer genomics datasets with internal and external experimental data to support innovative research projects.
Providing statistical support, creating insightful data visualizations, and contributing to the biological interpretation of complex datasets.
Maintaining code repositories, improving workflow documentation, and ensuring effective data storage management.
Preparing scientific manuscripts, grant applications, and research progress reports.
Anforderungen
Master's or PhD in Bioinformatics, Computational Biology, Computer Science, or a related analytical field.
Proficiency in Python or R, shell scripting (Bash) in a Linux/Unix environment, and experience working with High-Performance Computing (HPC) or cloud environments (AWS/GCP).
Proven track record in analyzing Next-Generation Sequencing (NGS) data (experience with single-cell analysis is a plus) and familiarity with workflow management systems such as Nextflow and Snakemake.
Excellent written and spoken English communication skills.
Prior research background in hemato-oncology, immunology, or cancer metabolism.
Hands-on experience with single-cell multi-omics data analysis (Seurat, Scanpy).
Experience in metabolomics or lipidomics data analysis.
Strong foundation in biostatistics and machine learning applications in oncology.
