The successful candidate will lead an ambitious interdisciplinary project at the interface of immunology, neuroscience, and cancer biology. The project will investigate how neural pathways regulate immune responses within tumours and how neuro-immune circuits can be manipulated to improve anti-tumour immunity. Research directions may include: how peripheral sensory or autonomic neurons regulate dendritic-cell and T-cell function neuronal sensing of inflammatory and tumour-derived signals neuropeptide and neurotransmitter regulation of anti-tumour immunity neural control of immune-cell trafficking, activation, and persistence within tissues identification of neuro-immune signalling pathways that promote or restrain tumour growth functional validation of new therapeutic targets at the neuro-immune interface Experimental approaches include in vivo tumour models, conditional mouse genetics, neuronal tracing, genetic and viral manipulation of neuronal populations, immune-cell depletion and adoptive transfer, spectral flow cytometry, cell sorting, imaging, transcriptomics, single-cell RNA sequencing, spatial transcriptomics, and functional neuro-immune assays.
As a joint venture of the University of Basel and the University Hospitals Basel, the Department of Biomedicine (DBM) brings together basic and clinical scientists to advance the understanding of health and disease. We are home to more than 67 research groups and over 800 employees across six locations in the heart of Basel. Our collaborative and international environment fosters innovation, excellence, and impactful research.
