Postdoctoral and PhD Positions in Neurotechnology: Drug/Biologics Carrier Formulation & Chemical Engineering for Focused Ultrasound-Mediated Brain Drug Delivery

Poste

Temps plein

Durée déterminée

Entry

Science & Recherche

Modalités

Zürich, Zurich

100%

Exigences

Bachelor

Permis UE/AELE

Compétences

Drug loading optimizationCarrier formulation chemistryClosed-loop control algorithmsRelease kinetics analysisPrecision neurotherapeuticsUltrasound technologyDrug Delivery SystemsMedical ImagingFormulation designTranslational researchReal-time systemsClinical safety assessment

Langues

Anglais

Description

The successful candidate will play a central role in the chemical formulation, engineering, and characterization of drug carriers for our focused ultrasound-mediated targeted drug delivery platform.

Responsabilités

Design and synthesis of ultrasound-responsive drug carrier formulations (e.g., microbubbles, nanodroplets, liposomes, or polymeric/lipid nanoparticles)
Optimization of drug loading, encapsulation efficiency, and release kinetics
Physicochemical characterization of carriers (size, zeta potential, stability, morphology)
Chemical engineering of carrier production processes (e.g., microfluidics, emulsification, sonication)
Assessment of carrier stability under ultrasound exposure and physiological conditions
In vitro and in vivo evaluation of drug loading, release, and therapeutic efficacy
Analytical method development for carrier and drug quantification (e.g., HPLC, DLS)
Integration of carrier formulations with focused ultrasound delivery systems
Collaboration with engineers and clinicians to prepare first-in-human clinical studies
Contribution to regulatory-compliant formulation development and quality control

Exigences

Bachelor-s degree and preferably also a Master-s degree for PhD position
PhD in Chemical Engineering, Chemistry, Pharmaceutical Sciences / Pharmaceutics, Materials Science, Biomedical Engineering, or a closely related field for postdoctoral position
Excellent academic records from excellent institutions
Strong quantitative and analytical skills, incl. programming (Python, MATLAB, or similar)
Experimental laboratory experience in drug formulation, nanoparticle/microbubble synthesis, colloid chemistry, or related fields
Hands-on experience with carrier characterization techniques (e.g., dynamic light scattering, zeta potential, HPLC, electron microscopy)
Microfluidic synthesis/purification expertise
Knowledge of drug loading, encapsulation efficiency, and release kinetics assessment
Strong motivation for translational drug delivery research and medical innovation
For postdoctoral applicants, a track record of peer-reviewed publications in drug delivery, nanomedicine, or pharmaceutical sciences
Good communication skills, being able to work independently as well as being part of a multidisciplinary team

Technologies

High-field 7 Tesla MRITwo-photon and confocal microscopyElectrophysiologyMicrofluidicsHPLCDynamic light scattering

Avantages

One of Europe-s leading research environments for neurotechnology and drug delivery
Collaboration with scientists and clinicians across ETH Zurich, the University of Zurich, University Hospital Zurich, and the Swiss Epilepsy Clinic Lengg
Access to advanced microfabrication facilities
Cell culture facilities
Behavioral neuroscience laboratories
Small- and large-animal research facilities

Entreprise

ETH Zurich

Research & Development

The Neurotechnology Group of Prof. Mehmet Fatih Yanik at ETH Zurich is recruiting outstanding postdoctoral researchers and PhD students to join a newly funded LOOP Zurich Flagship Project focused on advancing a breakthrough technology to clinic for non-invasive targeted drug delivery to the brain.