Postdoctoral Researcher in AI/ML-driven LC-MS for biopharmaceutical characterization

Role

Part-time

Fixed-term

Postdoctoral

Science & Research

Logistics

Sion, Valais

80%

Requirements

PhD

EU/EFTA permit

Skills

Data processingSample preparationMulti-attribute method (MAM)Host cell protein (HCP) analysisanalytical chemistryOrbitrap InstrumentsBiopharmaceutical characterizationScientific Publication WritingProtein biochemistryReportingLiquid injection GC/(HR)MSAI/ML project productionalisation

Languages

English

German

French

Description

Postdoctoral Researcher in AI/ML-driven LC-MS for biopharmaceutical characterization (80%) The Mass Spectrometry and Separation Sciences Laboratory (MS3L) at the HES-SO Valais-Wallis is seeking a highly motivated and skilled Postdoctoral Researcher with expertise in liquid chromatography high-resolution mass spectrometry (LC-HRMS), proteomics and biotherapeutic characterization. The successful candidate will combine hands-on Orbitrap-based analysis with active participation in the development of AI/ML-assisted data processing, working in a multidisciplinary team alongside software engineers and industry partners.

Responsibilities

Operate and maintain the LC-Orbitrap system, including method setup and routine troubleshooting.
Develop and execute sample-preparation protocols for intact-mass and peptide-mapping analysis of monoclonal antibodies and related biopharmaceuticals.
Perform HRMS data processing, interpretation and reporting, including multi-attribute method (MAM) and critical-quality-attribute workflows.
Analyze host cell protein (HCP) profiles.
Collaborate with software engineers to design, test and validate AI/ML tools for LC-HRMS data analysis and pipeline optimization.
Engage with industry partners to translate methods into application-ready workflows.
Contribute to manuscripts, project reports and scientific presentations.

Requirements

PhD in Analytical Chemistry, Biochemistry or a related field.
Demonstrated hands-on experience with LC-HRMS operation, in particular Orbitrap mass spectrometers.
Experience with protein/biopharmaceutical sample preparation and LC-MS data analysis.
Working proficiency in at least one scripting language (R, Python or similar) for data handling and analysis.
Strong organizational, communication and collaborative skills.

Tech stack

LC-HRMSOrbitrapAI/ML toolsscripting languages (R, Python)

Benefits

Stimulating applied research addressing real-world challenges in AI/ML for biopharmaceutical analysis.
Close collaboration with expert scientists, engineers and industry partners.
Access to state-of-the-art mass spectrometry instrumentation and computational tools.
Excellent teaching and laboratory facilities in a modern analytical chemistry environment, with the opportunity to develop teaching and student mentoring experience.
A position based in Sion, a picturesque town in the heart of the Alps and the sunny capital of Valais.

Company

HES-SO Valais-Wallis

Education

The University of Applied Sciences and Arts Western Switzerland Valais (HES-SO Valais-Wallis) has over 2,800 students. Through research and innovation, it contributes to economic and social development and the creation of jobs. The new Energypolis campus, home to the School of Engineering, EPFL and modern start-ups, is an innovative ecosystem for education and research.

Contact

Saša Miladinovic