Principal Scientist - Mid/Large Scale Oligonucleotide Synthesis, xRNA Therapeutics
Role
Full-time
Permanent
Senior
Science & Research
Logistics
BASEL, Basel-Stadt
On-site
Expected Annual Base Salary Range for role: 93,800.00 - 174,200.00 CHF Annual
Requirements
2+ yrs exp
PhD
EU/EFTA permit
Languages
English
Compensation
Expected Annual Base Salary Range for role: 93,800.00 - 174,200.00 CHF Annual
Responsibilities
Plan and execute medium- and large-scale solid-phase synthesis, purification, and analysis of chemically modified oligonucleotides (siRNAs, ASOs, and other emerging synthetic modalities) and conjugates to support our xRNA therapeutics portfolio.
Mentor and lead a team of scientists specialized in oligonucleotide synthesis, purification, analysis, and conjugation at millimole scale.
Collaborate with global discovery, development, and project teams to advance novel oligonucleotide chemistries and facilitate their successful transition from research into development.
Identify and implement innovative technologies, workflows, and manufacturing approaches to enhance operational excellence, production capabilities, and turnaround times of siRNA, ASO and other oligonucleotide modalities supporting in vivo and preclinical studies.
Communicate scientific findings and project updates effectively to internal and external stakeholders through presentations, technical reports, and patent applications.
Maintain high-quality scientific documentation, including electronic laboratory notebooks (ELNs), experimental protocols, technical reports, and project summaries.
Foster a culture of scientific excellence, collaboration, continuous learning, and solution-oriented problem solving.
Requirements
Ph.D. in Chemistry or related disciplines with a strong focus on oligonucleotide chemistry and synthesis.
Minimum 2-3 years of industry experience and proven expertise in mid- large-scale oligonucleotide solid phase synthesis, purification, analysis, conjugation, and other related processes.
Extensive experience operating and maintenance of AKTA Oligopilot/Oligosynt systems and AKTA Avant purification platforms, with strong proficiency in Unicorn software.
Strong hands-on experience with process development, method optimization and scale-up strategies of oligonucleotides.
Demonstrated leadership experience, including mentoring, and team management.
Strong communication skills and ability to work effectively in a matrixed cross-functional global teams- environment.
Tech stack
AKTA OligopilotAKTA AvantUnicorn software
Benefits
At Novartis, we-re committed to reimagining medicine together - and rewarding the people who make it happen.
In addition to your base salary, you may be eligible for a performance-based bonus depending on certain performance parameters.
The rewards of being part of our team go far beyond base pay and incentives.
We also offer a variety of competitive benefits in kind to help you thrive personally and professionally, such as insurance plans, retirement plans, wellbeing resources and global recognition programs.
In addition, we provide flexible and hybrid working options, where possible, and minimum 14 weeks paid parental leave.
