How you match

Skills

PharmacokineticsEnzyme PhenotypingDrug MetabolismCommunication SkillsProblem SolvingData AnalysisExperimental DesignOrganizational skillsCell cultureanalytical chemistryResearch MethodologyIn Vitro Methods

Languages

English

The role

We are now looking for a highly motivated Postdoctoral Researcher in the Drug Metabolism and Pharmacokinetics (DMPK) section of our Nonclinical Development department (2 years).

01Establish and evaluate New Approach Methodologies (NAMs) such as advanced in vitro hepatic systems to improve the prediction of human clearance, with a particular focus on low-turnover compounds.

02Compare intrinsic clearance data generated in conventional systems, such as human liver microsomes and cryopreserved hepatocytes, with data from more complex liver-cell models such as HepaRG, HepatoPac, TruVivo or related systems.

03Develop and apply robust LC-MS/MS bioanalytical methods to quantify parent compound depletion and, where appropriate, metabolite formation in those assays.

04Investigate the impact of nonspecific binding, compound stability, incubation recovery and free concentration on the interpretation of clearance data and support in vitro-in vivo extrapolation in collaboration with DMPK modelers.

05Assess the suitability of advanced hepatic systems for drug-metabolizing enzyme phenotyping in comparison with human liver microsomes, integrating metabolite identification where appropriate.

06Document, analyze and present experimental results in multidisciplinary project teams, and contribute to scientific reports, internal presentations, conference communications and peer-reviewed publications.

Requirements

↳PhD in pharmaceutical sciences, analytical chemistry, biochemistry, biology, pharmacology or a related discipline, with solid scientific training and a strong interest in applying experimental and analytical skills to DMPK questions.

↳Hands-on experience with cell culture and LC-MS/MS bioanalysis is required; experience with high-resolution MS and/or metabolite identification is an advantage.

↳Experience with in vitro ADME/DMPK assays, such as microsomal or hepatocyte stability, protein binding, drug-metabolizing enzyme phenotyping, is desirable.

↳Good understanding of drug metabolism, hepatic clearance mechanisms, enzyme phenotyping and in vitro-in vivo extrapolation, or strong motivation to develop expertise in these areas.

↳Proactive, collaborative and reliable personality with strong analytical thinking, excellent organizational and communication skills, and the ability to work effectively in a multidisciplinary and multicultural environment.

↳Excellent knowledge of English.

Benefits

Tech stack

LC-MS/MSHepaRGHepatoPacTruVivo

Company

Idorsia

Biotechnology

The purpose of Idorsia is to discover, develop, and commercialize innovative medicines to help more patients. Headquartered in Switzerland - a biotech-hub of Europe - Idorsia is a high-potential biopharmaceutical company, specialized in the discovery, development and commercialization of innovative small molecules, with the aim of transforming the horizon of therapeutic options.

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